Consistently with these results, also Machado et al. [19] described a prevalence of discrepancy due to elevated GH levels and normal IGF-I in patients studied during treatment with octreotide LAR and did not found relevant reduction in the prevalence of discordance when the cut off level of GH was changed from 2.5 to 1 ng/ml, as was instead reported in other class of acromegaly patients (such as at diagnosis or after surgery), since still discordant even when reducing GH cut-off. Here, IGF1 is linked to acromegaly.