The degree of discrepancy between GH and IGF-I depends at least in part on the cut-off used for the GH measurement: lower the GH cut-off, higher the probability of discrepancy, even though in the study by Machado et al. [19], no relevant reduction in the prevalence of discordance (that had instead been reported in other class of acromegaly patients, such as at diagnosis or after surgery) was observed in patients studied during treatment with octreotide LAR when the cut off level of GH was changed from 2.5 to 1 ng/ml. This evidence concerns the gene GH1 and acromegaly.