We studied 100 patients with acromegaly in SRLs (72 F; median age 64 years, IQR 53.5–71 years; median IGF-I 209 ng/ml, IQR 158.5–268.5 ng/ml; median IGF-I ULN 0.79, IQR 0.64–1.15; median IGFBP-3 2.6 μg/l, IQR 2.2–3.2 μg/l). The gene discussed is IGFBP3; the disease is acromegaly.