TNFRSF4 and neoplasm: In our previous study, we found that the combination therapy of cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs), OX40 antibody and cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) showed excellent anti-tumor efficacy in various cell lines, such as TC1, B16 and CT26, and the survival time of mice, after triple adjuvant therapy was significantly prolonged (Cai et al. 2021).