The mRNA expression levels of FADD in lung squamous cell carcinoma (LUSC), breast invasive carcinoma (BRCA), head and neck squamous cell carcinoma (HNSC), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD); FASLG in kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), BRCA, and KIRP; MLKL in colon adenocarcinoma (COAD), KIRC, and KIRP; FAS in KIRC, KIRP, and thyroid carcinoma (THCA); and TLR3 in KIRC were significantly upregulated. The gene discussed is MLKL; the disease is head and neck squamous cell carcinoma.