The high expression of TLR3 in lower grade glioma (LGG) and LUSC; FASLG in LGG, UVM, KIRC, and THYM; RIPK3 in LGG, KIRC, and LUSC; RIPK1 in LGG and THCA; FAS in LGG, UVM, and THYM; MLKL in LGG, UVM, and LUAD; FADD in LGG and HNSC; and TNF in UVM and CESC was associated with poor survival. This evidence concerns the gene TLR3 and central nervous system cancer.