Analysis of prognosis indicated that the hypermethylation of TLR3 in KIRC, STAD, and PCPG; MLKL in skin cutaneous melanoma (SKCM) and COAD, FASLG in BLCA, CESC, LUAD, and HNSC; FADD in LUAD; FAS in SARC, PCPG, and HNSC; RIPK3 in ACC; TNF in HNSC; RIPK1 in KIRC and KIRP was associated with poor prognosis, while the hypomethylation of MLKL in LGG and UVM; FASLG in LGG, UVM, THYM, and KIRP; FADD in ESCA; FAS in LGG, UVM, THYM, and KIRC; RIPK3 in LGG, LAML, and KIRC; TNF in LGG, UVM, THCA, and SARC; and RIPK1 in LGG, THYM, LUSC, ACC, and SKCM was associated with poor prognosis (Figure 2C). Here, MLKL is linked to cutaneous melanoma.