Compared with the mixture of α-Al2O3 nanoparticles and UPS, α-Al2O3-UPS elevated expression of CD80, CD86, MHC-I, and MHC-II-like molecules in DCs, suggesting a stronger ability to activate DCs and induce higher interferon-γ secretion, and also showed stronger tumor growth inhibition and survival prolongation in 4T1 tumor-bearing mice. Here, CD86 is linked to neoplasm.