Kong et al. (2017) constructed a lipid-coated biodegradable hollow mesoporous silica nanoparticles (MLB), which is co-encapsulated with all-trans retinoic acid (ATRA), doxorubicin (DOX), and interleukin-2 (IL-2) for chemoimmunotherapy to promote the tumor infiltration of active T lymphocytes and NK cells, and subsequent secretion of cytokines IFN-γ and IL-12, thus exerting better anti-tumor effects. The gene discussed is IFNG; the disease is neoplasm.