Ruan and his colleagues (2019) synthesized two gold nanoparticles targeting legumain proteins within glioma cell lysosomes and loaded them with DOX and HCQ (D&H-A-A&C), which were passively targeted to glioma sites and formed aggregates in situ, leading to massive accumulation of loaded DOX and HCQ at tumor sites. Here, LGMN is linked to central nervous system cancer.