CD80 and neoplasm: It was found that under NIR irradiation, BPQD released a large amount of heat, which increased the temperature of the irradiated part and promoted the continuous release of GM-CSF and LPS inside the thermosensitive gel, thus effectively recruiting dendritic cells to capture tumor antigens, inducing the expression of co-stimulatory molecules such as CD80 and CD86 and MHC-I and MHC-II and stimulating the activation and maturation of dendritic cells.