Liu et al. (2019) introduced ferrimagnetic vortex-domain iron oxide nanoring(FVIO) mediated mild magnetic hyperthermia and induced an efficient immunogenic cell death evidenced by upregulated CRT expression on the 4T1 breast cancer cells, more cancer cells being uptake by phagocytes, and increased polarization of macrophages, leading to more CD8+ CTL infiltrating into primary and distant tumor lesions. The gene discussed is CALR; the disease is breast cancer.