Therefore, Dong et al. (2020) prepared silica solid nanospheres (SiO2) and covalently attached model antigen OVA to the SiO2 surface to form a nanovaccine (OVA@SiO2) and found that the combined CpG-ODN application significantly upregulated the expression of co-stimulatory molecules (CD80, CD86), DC cell chemokine CCR7 and corresponding ligands (CCL19, CCL21), which on the one hand improved the ability of DCs to target migration to lymph nodes, and on the other hand promoted DC maturation activation and antigen cross-presentation for better anti-tumor effects. Here, CD80 is linked to neoplasm.