CD8A and neoplasm: It has been noted that after inoculation of a mouse ectopic colorectal tumor model with a therapeutic calcium phosphate nanovaccine functionalized with CpG and tumor model antigen, the number of tumor cytotoxic CD8+ T cells was significantly increased in a type I interferon (IFN-I)-dependent manner compared with systemic injection of soluble CpG and tumor model antigen, exhibiting a significant inhibition of tumor growth (Heße et al., 2019).