The research further combined PTT mediated by Fe3O4-R837SPs with ICB mediated by PD-L1 antibody on 4T1 breast cancer-bearing mice and found that the combined therapy not only eradicated the primary tumor but also inhibited the tumor’s lung and liver metastases by promoting CD45+ leukocyte infiltration into the distant tumor site. The gene discussed is CD274; the disease is neoplasm.