PGP and neoplasm: This study showed that after tumor cells internalized M-R@D-PDA-PEG-FA-D, PDA absorbed light energy and converted them inro hear energy under the NIR irradiation due to its high photothermal conversion ability, promoting the release of DOX from the outermost layer and apoptosis of tumor cells; meanwhile, the acidic environment of the endosome induced the breakage of the benzoic acid-imine bond connecting DOX and MSN, leading the releasing of DOX from the surface of MSN and an open state of the pore; then the internal P-gp siRNA was released into the cytoplasm for targeted degradation.