However, the MSN with larger pore size showed stronger antigen cross-presentation efficiency, which in turn significantly enhanced CD4+ and CD8+ T cell activation, secreted more IFN-γ, IL-4, and TNF-α, and increased the intensity of anti-tumor immune response, thus significantly inhibiting tumor growth and improving survival in B16F10 tumor-bearing mice. This evidence concerns the gene CD4 and neoplasm.