To investigate drug accumulation in tumors by LDLR‐mediated endocytosis, we determined Chol‐pyro fluorescence signals in tumor slices from MC38‐bearing C57BL/6 mice 24 or 48 h after intravenous injection of 200 μg of Chol‐pyro NCP with and without intratumoral injection of 1 μg α‐LDLR. This evidence concerns the gene LDLR and neoplasm.