The uptake of NCP particles by tumor cells via LDLR‐mediated endocytosis was confirmed using fluorescently labeled LDL (Dil‐LDL) and cholesterol‐pyropheophytin a (Chol‐pyro)‐loaded NCP as a surrogate for Chol‐SN38 in the shell and chlorin E6 (Ce6)‐loaded NCP as a surrogate for OxPt in the core (Figure S10, Supporting Information). Here, LDLR is linked to neoplasm.