It is important to note that with nal‐IRI alone treatment, the mice survive longer than untreated mice even though the tumor volumes with the nal‐IRI alone treatment are larger and, as per our previous data show, the CD44 cancer stem‐like cell subpopulations are enriched.[17] The reason is that primary tumor volume is not the only factor affecting survival; many other factors can contribute to the cause of death, including metastatic disease burden. Here, CD44 is linked to metastatic neoplasm.