BRAF and malignant colon neoplasm: Our results showed that in BCPAP (BRAF V600E mutant), 8505C cells (BRAF V600E mutant), and HCT116 colon cancer cells (BRAF V600E mutant), endogenous BRAF V600E was localized not only in the cytoplasm, but also in the mitochondria (Figure 6A).