To further confirm the relationship between BRAF V600E and cell death in papillary and anaplastic thyroid cancer cells, we knocked down endogenous BRAF V600E in the BRAF V600E mutant 8505C and BCPAP papillary and anaplastic thyroid cancer cells (Figure 2A). Here, BRAF is linked to thyroid gland undifferentiated (anaplastic) carcinoma.