Among these pathways, the mammalian target of rapamycin (mTOR) pathway is a driving force for the hyperproliferative phenotype of ADPKD cells [7], while the cystic fibrosis transmembrane conductance regulator (CFTR) mediates excessive fluid secretion into cyst lumen and promotes cyst enlargement in the kidney [8, 9]. Here, MTOR is linked to autosomal dominant polycystic kidney disease.