MAP3K3 and non-small cell lung carcinoma: Additionally, coimmunoprecipitation experiments showed that the EGFR‐TRAF4‐MEKK3 complex was readily detectable in NSCLC lysates but not in normal lung tissue, indicating the activation of the EGFR‐TRAF4‐MEKK3/ERK5 pathway (Fig. 7E).