We indeed found that Traf4 was overexpressed in human NSCLC, in which we detected the activation of EGFR, the EGFR‐TRAF4‐MEKK3 complex, and strong ERK5 phosphorylation, indicating that the signaling axis is hyperactivated in human NSCLC. This evidence concerns the gene MAP3K3 and non-small cell lung carcinoma.