We indeed found that Traf4 was overexpressed in human NSCLC, in which we detected the activation of EGFR, the EGFR‐TRAF4‐MEKK3 complex, and strong ERK5 phosphorylation, indicating that the signaling axis is hyperactivated in human NSCLC. The gene discussed is TRAF4; the disease is non-small cell lung carcinoma.