Similarly, it might have been expected that in those with CRCdiagnosed in the first round the profile of f-Hb would be markedly lower in thesecond round since, for the majority of participants, the bleeding lesion wouldhave been removed early in the interval between the two screening episodes.Those with adenoma (both LRA and HRA) in the first round also experienced ashift to lower f-Hb in the profile, but considerably less than for CRC,especially those with LRA. Here, GSTM1 is linked to adenoma.