PKM and B-cell chronic lymphocytic leukemia: However, when the effect of disease progression on the relative levels of PKM2 and PKM1 in circulating CLL cells was assessed, there was a decrease in PKM1 in cells from patients with progressive disease compared with cells from patients with indolent disease while PKM2 levels were maintained resulting in an increase in the PKM2:PKM1 ratio with disease progression (Suppl.