The CLL samples were divided into “histologically indolent” CLL or “histologically aggressive” CLL with the latter having increased large cells, large confluent PCs, or higher expression of Ki67, comparable to “accelerated” CLL.42,43 Notably, the histologically aggressive cases had an increased maximum standardized uptake value (SUVmax) on FDG/PET imaging, reflecting higher glucose uptake in vivo. The gene discussed is MKI67; the disease is B-cell chronic lymphocytic leukemia.