CD40LG and B-cell chronic lymphocytic leukemia: In this report, we demonstrate increased expression of glycolytic and mitochondrial markers within CLL PCs, with a concomitant increase in the metabolic activity of the CXCR4lowCD5high fraction of peripheral blood CLL cells that have recently egressed from the lymph node.15 We show that anti-IgM stimulation of CLL cells causes them to adopt many features of the “Warburg effect,” including increased glucose uptake, increased lactate production, and induction of glycolytic enzyme expression.