IHC can detect cell cycle and/or apoptosis regulators such as Ki67, PHH3, Cyclin D1, and p16 and can be used in conjunction with melanocytic markers such as HMB45, S100/S100A6, MITF, Mart-1/MelanA, and SOX10 for assessing the general architecture of the tumor (15, 68–72). This evidence concerns the gene CDKN2A and neoplasm.