For ESCC, the risk factors are older age, male sex, low body mass index, lower socioeconomic status, exposure to carcinogens (alcohol consumption, cigarette smoking, and betel quid chewing), low fruit/vegetable consumption, high meat/high temperature beverage intake, family members with esophageal cancer, history of HN cancer, poor oral hygiene, genetic polymorphism of alcohol-dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2), and motor disorders of the esophagus (e.g., achalasia) (7, 19, 21). The gene discussed is ADH1B; the disease is esophageal squamous cell carcinoma.