However, SRSF6 promoted CRC metastasis by inducing EMT independent of LINC01133, and the malignant phenotype was altered significantly by depleting SRSF6 in HT29 cells with high LINC01133 expression, in HCT116 cells with low LINC01133 expression, and in SW620 cells without LINC01133 expression. The gene discussed is SRSF6; the disease is colorectal carcinoma.