DKK1 and familial pancreatic carcinoma: also found that LINC01133 binds to the promoter region of DKK1, resulting in H3K27 trimethylation and decreased DKK1 expression; while the expression of Wnt-5a, MMP-7, and β-catenin increased upon LINC01133 binding to their respective promoting regions in pancreatic cancer (32).