IFNG and cancer: As expected, iMDK efficiently eliminated IFN-γ-induced MDK expression at both the mRNA and protein levels (Figures 6A, B), reversed IFN-γ-driven EMT activation determined by Western blotting and RT-qPCR (Figure 6B), and subsequently abrogated IFN-γ-triggered migration and invasion as shown in transwell assays (Figure 6C) in all examined cancer cell lines.