Although high ING5 expression was detected in gastric, colorectal, breast, and lung cancers (15–18), ING5 was found to be expressed at a low level in osteosarcoma, ovarian cancer, prostate cancer, and hepatocellular carcinoma (19–22), which might be possibly due to the different normal control tissues, tissue specificity of ING5 expression and the distinct infiltration contents of interstitial cells, and subsquently result in their different biological functions. This evidence concerns the gene ING5 and osteosarcoma.