Here, we for the first time abrogated ING5 in gastric parietal, stem-like, pit, chief, and pdx1-positive cells and found poorly, moderately, or well-differentiated gastric carcinoma in Atp4b-cre;ING5f/f, Pdx1-cre;ING5f/f, and K19-cre;ING5f/f mice, suggesting that ING5 deletion in parietal, stem-like, and Pdx1-positive cells of gastric epithelium might play an important role in the histogenesis of gastric cancer. Here, PDX1 is linked to gastric cancer.