Reportedly, SRF expression was frequently elevated in a panel of metastatic gastric cancer cells and tissues, and high expression of SRF was significantly associated with a more aggressive phenotype and poor prognosis in gastric cancer patients (36) or facilitating crosstalk between myofibroblasts and cancer cells in an SDF1-CXCR4-dependent manner (37). This evidence concerns the gene CXCL12 and gastric cancer.