IL-8 is a common cytokine to recruit neutrophils to the sites of inflammation, which can be released by multiple cancer cells including glioblastoma, diffuse large B-cell lymphoma (DLBCL), bladder cancer, and CRC, and the released IL-8 can stimulate NETosis in human neutrophils ex vivo (7, 14, 36–38). The gene discussed is CXCL8; the disease is urinary bladder carcinoma.