RNPC3 and systemic lupus erythematosus: In addition, anti-ribonucleoprotein (anti-RNP) antibodies in patients with systemic lupus erythematosus (SLE) can induce NETosis, and SLE NETs activate plasmacytoid dendritic cells (PdCs) to produce high levels of IFN-α, which renders neutrophils more susceptible to NETosis upon stimulation of anti-RNP antibodies (53).