In addition, the activation of the NFκB pathway in M protein-treated MDA-MB-231 cells also induced the expression of inflammatory cytokines, including IL6, IL8, and TNFα, which are involved in tumor initiation and homing and metastasis of BCC (34–36) and might contribute to the amplification of the cytokine storm. Here, CXCL8 is linked to skin basal cell carcinoma.