However, histological analysis of xenografted tumors treated over the long term, with OxA, gemcitabine, Nab-paclitaxel, OxA plus gemcitabine, or OxA plus Nab-paclitaxel revealed that OX1R was always expressed in tumor cells after 50 days of these different treatments. Here, HCRTR1 is linked to neoplasm.