In fact, OxA/OX1R directly activates mitochondrial apoptosis in pancreatic cancer cells, whereas gemcitabine inhibited the DNA synthesis in pancreatic cancer cells, inducing cytotoxicity that leads to apoptosis (30), and Nab-paclitaxel inhibited microtubule dynamics inducing cytotoxicity that also leads to apoptosis (12). Here, HCRTR1 is linked to pancreatic neoplasm.