TNF and obesity due to melanocortin 4 receptor deficiency: Obesity is a chronic disease strongly associated with a low but prolonged inflammatory state characterized by the presence of increased cytokines in blood and tissues, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), all of which precipitate insulin resistance in some tissues and ultimately cause type 2 diabetes mellitus and other health complications [1].