In addition to the Notch/NF-κB pathway, there are other important signaling pathways in HCC cells for resistance to antitumor drugs (Zhu et al., 2019; Ma et al., 2020; He Y et al., 2021; He W et al., 2021; Guan et al., 2021; Yan et al., 2021). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.