NFKB1 and hepatocellular carcinoma: In this study, five HCC-related, molecularly-targeted drugs were selected, but the Notch/NF-κB pathway can activate/desensitize HCC cells to molecularly-targeted drugs through cell-promoting, anti-apoptotic-related, and epithelial-mesenchymal transition-related factors, and eventually induce cell resistance to molecularly-targeted drugs.