In the largest NAFLD GWAS, we observed that the odds of NAFLD would increase if inhibiting IL-6 signaling pathway [OR = 1.99 (1.27, 3.13), p-value = 0.003] where the inhibitive effect was measured by IL-6 level and proxied by SNP rs2228145. The gene discussed is IL6; the disease is metabolic dysfunction-associated steatotic liver disease.