Twelve genes were enriched in 16 signal pathways, including the PI3K-AKT pathway, JAK-STAT pathway, HIF-1 pathway, pathways in cancer, axon guidance, focal adhesion, proteoglycans in cancer, cytokine-cytokine receptor interaction, et al. Enrichment pathway information is shown in Figs. 3 (according to Table 2, p-value < 6.36 E − 05) and 2. This evidence concerns the gene PIK3CD and cancer.