Interestingly, tPA plasma concentration was found to correlate with cardiovascular disease-related traits, such as triglycerides, total cholesterol, systolic blood pressure, diastolic blood pressure, body mass index, or fasting insulin level (Eliasson et al., 1994a,b, 1997; Koike et al., 1998; Lowe et al., 2004; Asselbergs et al., 2007). The gene discussed is PLAT; the disease is cardiovascular disorder.