As for the effects of pathological aging on tPA plasma levels, previous studies reported discordant findings, with studies showing either decrease (see Whelan et al., 2019; Ziliotto et al., 2021 for review), increase (Hagnelius et al., 2010), or no differences (Marksteiner et al., 2014) in AD patients compared to controls . Here, PLAT is linked to Alzheimer disease.