Although there was no difference in serum-free fatty acid (FFA) level between Mdm2-AKI mice and WT controls (Figures 4F and S4F), the results from liquid chromatography-tandem mass spectrometry (LC-MS/MS) showed that adiponectin was downregulated and some pro-inflammatory factors, including haptoglobin, serum amyloid A protein 1/2 (SAA1/SAA2) and lipopolysaccharide-binding protein (LBP), were upregulated in the serum of the Mdm2-AKI mice on a HFD compared to WT controls (1.5-fold-change criterion, FDR <0.01) (Figure 4G). Here, HP is linked to acute kidney injury.