MDM2 and acute kidney injury: The results showed that more senescent cells were identified via β-galactosidase staining (Figures 4A and S4A) and the mRNA level of senescence-related gene cyclin-dependent kinase inhibitor 1A (CDKN1A, p21) was upregulated in the eWAT, but not iWAT, of Mdm2-AKI mice on a HFD (Figures 4B and S4B).