Furthermore, under HFD feeding condition, MDM2 overexpression caused eWAT dysfunction, such as cellular senescence, apoptosis, and inflammation through ubiquitin-mediated STEAP4 degradation, highlighting the crucial role of the MDM2-STEAP4 axis in maintaining healthy adipose tissue function and improving hepatic steatosis. This evidence concerns the gene STEAP4 and Hepatic steatosis.