MDM2 and acute kidney injury: By comparing WT mice injected with AAV9-STEAP4 (WS) with Mdm2-AKI mice injected by AAV9-STEAP4 (MS), we found that STEAP4 restoration in eWAT had no apparent effects on adipose-specific MDM2 overexpression-aggravated changes in body weight and heat production (Figures 8A and 8B), but alleviated MDM2-aggravated insulin intolerance (Figure 8C).