Consistently, the mRNA level of the anti-apoptotic gene B-cell lymphoma-2 (Bcl2) decreased in the eWAT of Mdm2-AKI mice on a HFD for 12 weeks, whereas that of the pro-apoptotic gene BCL2 associated X (Bax) increased in the eWAT of Mdm2-AKI mice on a HFD for 12 or 8 months (Figures 4D and S4D). This evidence concerns the gene MDM2 and acute kidney injury.