A recent study demonstrated that MDM2 haploinsufficient in adipocytes induced overt obesity, glucose intolerance, and hepatic steatosis through a novel interplay with the transcriptional cofactors MORC Family CW-Type Zinc Finger 2 (MORC2) and LIPIN1 (Hallenborg et al., 2021). Here, MDM2 is linked to fatty liver disease.