AKT1 and cancer: The previous studies suggested that PAB could block malignant behaviors in many cancers, such as driving cell apoptosis by downregulating phosphatidylinositol-3 kinase/protein kinase B (PI3 K/Akt) signaling in gastric cancer [24, 25], and inhibiting cell proliferation by blocking Akt-GSK-3β-catenin signaling in HCC [7].