Stereotactic radiotherapy combined with the TP chemotherapy regimen for treating NSCLC contributes to improving the quantitative volume dose distribution of patients, effectively controlling the irradiated dose and irradiated volume of main organs, elevating the prognosis of patients and the levels of CYFRA21-1 and MALAT1 in blood. The gene discussed is MALAT1; the disease is non-small cell lung carcinoma.