Following the microglia activation, the liberation of some inflammatory mediators, including nitric oxide (NO), inducible NO synthase (iNOS), interleukin (IL)-1β, IL-6, and tumour necrosis factor-α (TNF-α) is increased in the CNS microenvironments, in which they possess an important role in proceeding neurodegenerative diseases [9, 12, 13]. The gene discussed is NOS2; the disease is neurodegenerative disease.