INS and hypertensive disorder: Although we have known that polyunsaturated FAs positively affect insulin sensitivity, cardiovascular, mental health, and development and reduce hypertension and inflammation (49), the increase of serum-free FAs will lead to systemic low-grade inflammation, and the increase of HF-derived free FAs in the intestinal cavity will lead to the increased production of pro-inflammatory cytokines in the intestinal tract (50).