CYP8B1 and hydrops fetalis: The expression levels of genes associated with hepatic FA synthesis (Fasn, Scd1) were downregulated in the HF group compared with those in the CD group (p < 0.05) (Figure 1C), but the expression of key genes involved in BA synthesis (Cyp7b1, Cyp8b1) was upregulated in HF fed livers (p < 0.05).