GPC3, ACSM3, SPINK1, COL15A1, TP53I3, RRAGD, and CLDN10 were identified as potential new immune-related diagnostic biomarkers with high diagnostic value, which may serve as ideal biomarkers for the diagnosis of HCC, as well as for the early stage of HCC. Here, COL15A1 is linked to hepatocellular carcinoma.