GPC3, ACSM3, SPINK1, COL15A1, TP53I3, RRAGD, and CLDN10 were identified as potential new immune-related diagnostic biomarkers with high diagnostic value, which may serve as ideal biomarkers for the diagnosis of HCC, as well as for the early stage of HCC. The gene discussed is TP53I3; the disease is hepatocellular carcinoma.