FTO and Stroke: FTO has been reported to promote angiogenesis and reduce myocardial fibrosis after myocardial ischemia, however, in the brain, it is predominantly expressed in neurons, whereas downregulation of FTO and ALKBH5 after stroke can induce secondary brain injury by destroying neurons (Chokkalla et al., 2019; Mathiyalagan et al., 2019; Xu et al., 2020).