Normalizing the gene-dose of Dyrk1a in glutamatergic neurons of the Dp(16)1Yey brain improved long-term explicit memory (Brault et al., 2021); this may have been the result of the gene's important role in neurodevelopment and further studies are thus needed to investigate how three-copies of DYRK1A may impact cognitive decline associated with AD-DS. Here, DYRK1A is linked to Mental deterioration.