Normalizing the gene-dose of Dyrk1a in the Ts65Dn mouse model of DS rescued cholinergic neuron degeneration and modulated the density of senescent cells in the cingulate cortex and hippocampus back to euploid levels (García-Cerro et al., 2017), however, how this affected cognitive decline was not studied. Here, DYRK1A is linked to Mental deterioration.