APOE and atherosclerosis: To explore how CVD affects the transcriptional program of bone marrow endothelial cells, that is, the signaling that contributes to the observed phenotypic adaptions in the bone marrow, we used RNA-seq to compare bone marrow endothelial cells isolated by flow cytometry from naive controls to cells collected from hypertensive mice, to Apoe−/− mice with atherosclerosis and to mice 4 d after MI (Supplementary Table 1 and Fig. 7a–h).