This review will explore the potential of a few selected TCMs in reducing misfolding of Aβ and tau proteins and conferring neuroprotection towards PCD, by focusing on preclinical and clinical research progress achieved on Artemisia annua, Ginseng, Astragalus membranaceus, and Ginkgo biloba leaf extract and derived chemicals as anti-AD compounds using in vitro neuronal cell cultures, in vivo animal models of AD, and selected few clinical trials. This evidence concerns the gene MAPT and Alzheimer disease.