Similar research findings indicated that Astragalus extract can significantly improve the learning and memory abilities of AD mice and downregulate caspase-3 mRNA levels, decrease the expression of the caspase-3 protein and cytochrome c in the hippocampus and neocortex, and inhibit caspase-9 and caspase-3 activities [96]. Here, CASP3 is linked to Alzheimer disease.