Ginkgo biloba extract EGb761 induced clearance of Aβ by regulating RAGE expression in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia [218] and reduced the Aβ-induced upregulation of RAGE in an in vitro bEnd.3, an immortalized mouse cerebral microvessel endothelial cell line model [219]. This evidence concerns the gene AGER and Hypoglycemia.