In the conventional pathway, TGF-β acts as a tumor suppressor to induce cell differentiation, senescence, and apoptosis via Smad protein-dependent signaling by inducing cell cycle arrest (in the G1 phase) and protein kinase inhibitors (p21 and p15) and by inhibiting proliferation drivers such as c-myc [26]. This evidence concerns the gene TGFB1 and neoplasm.