We also showed that convalescent plasma from COVID-19 patients blocked the entry of pseudotyped SARS-CoV-2 wild-type, Alpha, Beta, Gamma, and Kappa into ACE2-293T cells, while all convalescent plasma samples except ConV-9 failed to prevent the Omicron infection, underscoring the immune evasion of Omicron. Here, ACE2 is linked to COVID-19.