The type I IFN-mediated immune response represents the first line of host defense against viral infection due to the engagement of pattern recognition receptors (PRRs), including retinoic-acid inducible gene-I (RIG-I), melanoma differentiation-associated protein 5 (MDA-5), and toll-like receptors (TLRs) [12,13]. Here, IFIH1 is linked to viral infectious disease.