Viral restriction factors that have been reported in relation to nonprogressive HIV infection include, among others, the sterile alpha motif and histidine-aspartate domain 1 (SAMHD1), tetherin, APOBEC3G, TRIM-5α, serin incorporator 3/5 (SERINC3 and SERINC5), B-lymphocyte-induced maturation protein-1 (BLIMP-1), endoplasmic reticulum class I α-mannosidase (ERManI), translocator protein (TSPO), guanylate-binding protein 5 (GBP5), and zinc-finger antiviral protein (ZAP) [8,40,41,42]. This evidence concerns the gene ZC3HAV1 and HIV infectious disease.