Secondly, assessing the immune status at moment of infection (tBTI), 7 out of 11 subjects displayed waning antibody responses (e.g., anti-S IgG: Supplementary Figure S3a) and 2 out of 4 subject had decreasing IFN-γ release upon specific restimulation (Supplementary Figure S3b) compared to t3m. This evidence concerns the gene IFNG and infection.