PROS1 and infection: In general, subjects with a smoking habit showed less anti-S protein antibodies regardless their infection status (non-vaccinated: FC = −1.65, p-value = 0.0066; infected/Nprot+: FC = −1.61, p = 0.0001; infected/Nprot−: FC = −1.73, p = 0.0751; non-infected: FC = −1.32, p < 0.0001), although this decrease was substantially smaller and not statistically significant for subjects vaccinated with mRNA-1273 that had no previous contact with the SARS-CoV-2 (Supplementary Table S3).