According to our results and after controlling for potential confounders, clinical variables previously linked to poor prognoses regarding SARS-CoV-2 infection, such as age, BMI and arterial hypertension, were positively associated with increasing levels of anti-S protein antibody titer after vaccination [27,28,29,30,31], but exclusively in infected/Nprot+ subjects. The gene discussed is PROS1; the disease is Hypertension.