Although we cannot exclude the possibility that HIV viremia and low CD4 count affect seropositivity for SARS-CoV-2, it has been reported that HIV-associated parameters (HIV plasma viral load, CD4 and CD8 cell counts, and CD4:CD8 ratio) were not significantly associated with SARS-CoV-2 antibody losses in PLWH on stable ART from Durban, KwaZulu-Natal, South Africa, recruited after the first COVID-19 wave, between June 2020 and November 2020 [31]. The gene discussed is CD8A; the disease is COVID-19.