Compared with discharged COVID-19 patients, the levels of WBC, NEU, PLR, SII, D-dimer, CRP, BUN, and ferritin at the time of hospital admission were significantly higher in nonsurviving patients in the subgroup of hypertension (p < 0.0001), while the levels of PLR and SII were also significantly higher in nonsurviving patients in the subgroups of obesity and diabetes. The gene discussed is CRP; the disease is COVID-19.