In our multivariate analysis, we found three variables independently associated with disease severity, critical or severe, in our groups of COVID-19 patients—age, D-dimer, and LDH—and six variables as mortality risk factors: CRP, ferritin, NEU, NLR, PLR, and SII, Tables S1 and S2 in the Supplementary Material. This evidence concerns the gene CRP and COVID-19.