Our results showed that females accounted for a higher proportion of acute hepatitis B and E than males, and both the younger and the older populations were more affected by acute viral hepatitis, while many sexually active people also suffered from acute hepatitis B. It was reported that female patients tend to exhibit more severe cases of overt acute hepatitis B, indicated by a prolonged prothrombin time, [26] hence, the need to focus on the prevention against HBV infection for females. The gene discussed is F2; the disease is hepatitis B virus infection.