Host genetic factors that increase the prevalence of NAFLD in the general population, such as polymorphisms in the genes encoding patatin-like-phospholipase domain-containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), may also impact liver disease in PLWH [38,39]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.