Thus, the repertoires of autoantibodies against extracts of HEp-2, ds-DNA, human albumin, and transferrin as autoantigens indicated that in AD dogs, there are higher levels of IgG1 autoantibodies and a higher seroprevalence than in SD dogs, in which there are lower levels and lower seroprevalences of total IgG and IgG2 [88]. This evidence concerns the gene TF and Alzheimer disease.