In clear cell renal carcinoma (ccRCC) patients, TREM2+ TAMs were defined by the expression of TREM2, APOE, and C1QA-C, along with other macrophage markers associated with immunosuppression, such as LILRB5, MERTK, STAB1, and IGF1 [71]. This evidence concerns the gene TREM2 and nonpapillary renal cell carcinoma.