Human breast cancer cells also express the CXCL-13 receptor, which induces the migration of CXCR-5-expressing B cells, and the coculture of CXCR-5-expressing B cells with cancer cells such as MCF-7 can induce the apoptosis of B cells and the appearance of a Breg population [49]. The gene discussed is CXCR5; the disease is breast cancer.