Our results showed that, in China, although the number of reported pertussis cases significantly decreased after the COVID-19 pandemic in 2020, the seroprevalence of anti-PT IgG antibodies in adults of childbearing age was close to that observed in the pre- COVID-19 era, suggesting that the true incidence of pertussis is still significantly underestimated in China. This evidence concerns the gene F2 and pertussis.