Many studies have documented that crocin, which is extracted from saffron stigmas, exerts antioxidant and anti-inflammatory therapeutic effects in several diseases, including osteoarthritis [32] and osteoporosis, since it downregulates osteoclast differentiation via inhibition of JNK and NF-κB signaling pathways [33]. The gene discussed is NFKB1; the disease is osteoporosis.