GFAP and brain neoplasm: In vivo brain imaging of the RG-2 intra-cranial tumors with the CAV PNA or the GFAP PNA antisense radiopharmaceutical demonstrated the under-expression of the GFAP mRNA (Figure 14F) and the over-expression of CAV mRNA (Figure 14G) in the intra-cranial brain tumor, providing the PNA was conjugated to the TfRMAb Trojan horse [806].