At 5 days following implantation of 500,000 U87 glioma cells in the caudate-putamen, mice were treated weekly by IV administration of (a) saline, (b) HIRMAb/TfRMAb-THLs encapsulating the luciferase expression plasmid, or (c) HIRMAb/TfRMAb-THLs encapsulating the EGFR antisense RNA expression plasmid. Here, EGFR is linked to central nervous system cancer.